Technology
Capsant’s Hi-Spot technology is a high throughput in-vitro tissue platform for drug discovery. Hi-Spot core technology produces 3D tissue cultures from reconstituted primary tissues or from stem cells allowing long-term culture in a static air-liquid interface. If derived from tissues, they are first dissociated and then re-aggregated on a semi-porous membrane, after which they develop and reorganize in-vitro, giving rise to 3D ‘organ-like’ cultures. If derived from progenitor stem cells, Hi-Spots are directly formed on the semi-porous membrane and can differentiate into tissues. These Hi-Spot cultures represent a high-density mixed organotypic culture system in a static air liquid interface.
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